
CAS No:132684-60-7
Formula:C21H23NO4
Synonyms:FMOC-L-TLE-OH;FMOC-L-T-BUTYLGLYCINE;FMOC-L-TERT-LEUCINE;FMOC-TLE-OH;FMOC-TBU-GLYCINE;FMOC-TBU-GLY-OH;FMOC-ALPHA-T-BUTYL-GLY-OH;FMOC-ALPHA-T-BUTYLGLYCINE
China Export:From 2018.11 to 2019.11, total export volume of Fmoc-L-tert-leucine from China was 76,865,630KG while total export value was $825,816,556. The biggest proportion of exporting volume in the last 12 months was 14.24% in 2019.05.
Chemical Products Fmoc-L-tert-leucine Description
solid
Chemical Products Fmoc-L-tert-leucine Basic Attributes
CAS No:132684-60-7
Molecular Formula :C21H23NO4
Molecular Mass :353.41
Exact Mass :353.162720
PSA :75.6 A^2
LogP :4.4
InChIKeys :VZOHGJIGTNUNNC-GOSISDBHSA-N
H-bond Acceptor :4
H-bond Donor :2
SP3 :0.33
RBN :6
Chemical Products Fmoc-L-tert-leucine Characteristics
Density :1.209±0.06 g/cm3(Predicted)
Melting Point :124-127 °C
Bolling Point :554.1±33.0 °C(Predicted)
Flash Point :288.9±25.4 °C
Refractive Index :1.584
Storage Condition :2-8°C
Chemical Products Fmoc-L-tert-leucine Safety Information
Hazard Class :IRRITANT
HS Code :29242990
UN No. :NONH for all modes of transport
WGK_Germany :3
Safety Instructions :22-24/25
P Code :P261, P264, P271, P280, P302+P352, P304+P340, P312, P321, P332+P313, P362, P403+P233, P405, P501
Hazard Statements :H315
Chemical Products Fmoc-L-tert-leucine Production Methods
Take 500mL of the reaction bottle, Chiral amino acids S-3b (5.1 g, 38.6 mmol) were added to the reaction flask, respectively, Dioxane (40 mL) and10percent sodium carbonate (100 mL), The reaction flask was placed in an ice bath, mechanically stirred, To the dropping funnel was added l-chloroformate-9-fluorenylmethyl ester (10.0 g, 38.6 mmol) andDioxane (100 mL), Slowly drop into the reaction flask and gradually return to room temperature and stir overnight.After completion of the reaction, add water 100mL, extracted with 50mL ether three times, take the water phase into the ice bath to cool, add 1M dilute HCl to PH 1.The aqueous solution was extracted three times with 50 mL of ethyl acetate.The oil phase was combined and dried over magnesium sulfate and filtered to dryness to give intermediate S-4b (14.3 g, 96percent).