Fragment based drug discovery is a structure-based drug design technique that utilizes biophysical methods to identify small molecule fragments that weakly bind to targets of interest. Fragment compounds, which typically weigh less than 300 Daltons, have lower chemical complexity and higher "druggability" than conventional lead compounds identified in high-throughput screening.
Global Fragment Based Drug Discovery Market allows discovery of novel chemical starting points for drug development in an efficient and cost-effective manner. Fragment screening identifies low affinity fragments that can guide medicinal chemistry efforts in growing fragment hits into potent and selective lead compounds.
The Global Fragment Based Drug Discovery Market is estimated to be valued at USD 1.21 Bn in 2024 and is expected to reach USD 2.60 Bn by 2031, growing at a compound annual growth rate (CAGR) of 11.6% from 2024 to 2031.
Key players operating in the global fragment based drug discovery market are Astex Pharmaceuticals, Alveus Pharmaceuticals Pvt. Ltd., Beactica AB, Crown Bioscience Inc., Emerald Cloud Lab, Evotec AG, Kinetic Discovery Limited, Panacea Pharma LLC, Sprint Bioscience, and Sygnature Discovery.
The key opportunities in the market include expanding applications of fragment based screening across various therapeutic areas and partnerships with pharmaceutical companies for development of clinical candidates. Fragment screening and hit expansion has led to several drug candidates entering clinical trials, validating the technique. Global companies are also focusing on expanding their geographic footprint in emerging markets like Asia Pacific and Latin America. Strategic collaborations provide opportunities to access novel targets and technologies, as well as regional market expertise. The increasing R&D expenditure on drug development in developing regions will further stimulate the demand.
Market drivers Rising focus on developing small molecule therapeutics is a major market driver. Small molecules have advantages over biologics such as oral administration, lower cost of development and manufacturing. Fragment based screening is well-suited for development of orally available small molecule drugs. The technique has shown success in generating clinical candidates, validating its potential.
Market restraints High costs associated with establishing infrastructure for fragment screening and data analysis can restrain market growth. Specialized equipment and skilled labor is required. Accuracy of biophysical methods can also be a challenge. Proportion of fragments advancing to clinical stages is also relatively low currently. Overcoming these challenges will be important for sustained growth of the fragment based drug discovery market.
Segment Analysis The Global Fragment Based Drug Discovery Market is dominated by structure based drug discovery segment owing to high adoption by pharmaceutical companies. Structure based drug discovery involves analyzing protein structures and identifying fragments that can bind to target proteins. This sub segment holds over 40% share in the overall market as it provides efficient screening of chemical fragment libraries and lead optimization. X-ray crystallography is widely used technique in this sub segment to determine 3D structures of biomolecules and analyze fragment binding.
North America captures around 35% share in the Global Fragment Based Drug Discovery Market and is the fastest growing region. Presence of major pharmaceutical companies and research institutions involved in drug discovery research drives the market in the region. Increase in R&D expenditure by the players operating in the US and Canada is boosting adoption of fragment based drug discovery techniques. This is supporting market growth. Asia Pacific is projected to witness high growth during the forecast period owing to increasing government initiatives to promote life science research in countries like China and India.
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